Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005110)
Formula
SVG example
6-ketoreduction
Reactant Hydromorphone Product 6-alpha-hydromorphol
Reactant Info Product Info
Metabolic Type Reduction - 6-ketoreduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005138 Hydromorphone Hydromorphone-3-glucuronide Conjugation - Glucuronidation Hydromorphone [1], [2], [3]
MR005137 Hydromorphone Norhydromorphone Oxidation - N-demethylation Hydromorphone [4]
MR011211 Hydromorphone Hydrocodone M462 Conjugation - Glucuronidation Hydrocodone [5]
MR011202 Hydromorphone Hydromorphol Reduction - Ketone reduction Hydrocodone [5]
MR005122 Hydromorphone Hydromorphone glucuronide conjugate Conjugation - O-glucuronidation Hydrocodone bitartrate [6]
MR005111 Hydromorphone 6-beta-hydromorphol Reduction - 6-ketoreduction Hydrocodone bitartrate [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007115 Dihydrocodeine Dihydromorphine Oxidation - O-demethylation Dihydrocodeine [7], [8]
MR005118 6-alpha-hydrocodol 6-alpha-hydromorphol Oxidation - O-demethylation Hydrocodone bitartrate [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007116 Dihydromorphine DHM-glucuronides Conjugation - Glucuronidation Dihydrocodeine [7]
MR005119 6-alpha-hydromorphol 6-alpha-hydromorphol glucuronide conjugate 1 Conjugation - O-glucuronidation Hydrocodone bitartrate [6]
MR005120 6-alpha-hydromorphol 6-alpha-hydromorphol glucuronide conjugate 2 Conjugation - O-glucuronidation Hydrocodone bitartrate [6]
References
1 Hydromorphone
2 Opioid pharmacokinetic drug-drug interactions. Am J Manag Care. 2011 Sep;17 Suppl 11:S276-87.
3 Opioid therapies and cytochrome p450 interactions. J Pain Symptom Manage. 2012 Dec;44(6 Suppl):S4-14.
4 Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone. Xenobiotica. 2004 Apr;34(4):335-44.;
5 Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite
6 DrugBank(Pharmacology-Metabolism):Hydrocodone bitartrate
7 Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing. Br J Clin Pharmacol. 1999 Sep;48(3):317-22.
8 Dihydrocodeine: safety concerns

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