Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005137)
Formula
CYP3A4 ...
SVG example
N-demethylation
Reactant Hydromorphone Product Norhydromorphone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005138 Hydromorphone Hydromorphone-3-glucuronide Conjugation - Glucuronidation Hydromorphone [1], [2], [3]
MR005110 Hydromorphone 6-alpha-hydromorphol Reduction - 6-ketoreduction Hydrocodone bitartrate [4]
MR011211 Hydromorphone Hydrocodone M462 Conjugation - Glucuronidation Hydrocodone [5]
MR011202 Hydromorphone Hydromorphol Reduction - Ketone reduction Hydrocodone [5]
MR005122 Hydromorphone Hydromorphone glucuronide conjugate Conjugation - O-glucuronidation Hydrocodone bitartrate [4]
MR005111 Hydromorphone 6-beta-hydromorphol Reduction - 6-ketoreduction Hydrocodone bitartrate [4]
References
1 Hydromorphone
2 Opioid pharmacokinetic drug-drug interactions. Am J Manag Care. 2011 Sep;17 Suppl 11:S276-87.
3 Opioid therapies and cytochrome p450 interactions. J Pain Symptom Manage. 2012 Dec;44(6 Suppl):S4-14.
4 DrugBank(Pharmacology-Metabolism):Hydrocodone bitartrate
5 Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.