Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005118)
Formula
CYP2D6 ...
SVG example
O-demethylation
Reactant 6-alpha-hydrocodol Product 6-alpha-hydromorphol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005114 Hydrocodone bitartrate 6-alpha-hydrocodol Reduction - 6-ketoreduction Hydrocodone bitartrate [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007115 Dihydrocodeine Dihydromorphine Oxidation - O-demethylation Dihydrocodeine [3], [4]
MR005110 Hydromorphone 6-alpha-hydromorphol Reduction - 6-ketoreduction Hydrocodone bitartrate [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007116 Dihydromorphine DHM-glucuronides Conjugation - Glucuronidation Dihydrocodeine [3]
MR005119 6-alpha-hydromorphol 6-alpha-hydromorphol glucuronide conjugate 1 Conjugation - O-glucuronidation Hydrocodone bitartrate [5]
MR005120 6-alpha-hydromorphol 6-alpha-hydromorphol glucuronide conjugate 2 Conjugation - O-glucuronidation Hydrocodone bitartrate [5]
References
1 Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog
2 CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004 Mar;57(3):287-97.
3 Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing. Br J Clin Pharmacol. 1999 Sep;48(3):317-22.
4 Dihydrocodeine: safety concerns
5 DrugBank(Pharmacology-Metabolism):Hydrocodone bitartrate

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