General Information of This Metabolic Reaction (MR) (ID: MR005236)
Formula
UGT1A3 ...
SVG example
Glucuronidation
Reactant Retigabine Product Retigabine-N2-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005238 Retigabine N-Acetyl Retigabine Conjugation - N-acetylation Retigabine [1]
MR005237 Retigabine Retigabine-N4-glucuronide Conjugation - Glucuronidation Retigabine [1], [2], [3]
References
1 Retigabine: the newer potential antiepileptic drug
2 Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999 May;27(5):605-12.
3 N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II. Metabolism. 2006 Jun;55(6):711-21.

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