Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR005238)
Formula	N-acetylation
	Reactant	Retigabine		Product	N-Acetyl Retigabine
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Conjugation - N-acetylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005236	Retigabine	Retigabine-N2-glucuronide	Conjugation - Glucuronidation	Retigabine	[1], [2], [3]
MR005237	Retigabine	Retigabine-N4-glucuronide	Conjugation - Glucuronidation	Retigabine	[1], [2], [3]

References
1	Retigabine: the newer potential antiepileptic drug
2	Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999 May;27(5):605-12.
3	N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II. Metabolism. 2006 Jun;55(6):711-21.

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