Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM004883)
DM Name
20-O-beta-D-Glu
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004
Silymarin
Conjugation - Glucuronidation Silymarin [1] , [2]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME0072
Silymarin
Conjugation - Glucuronidation Silymarin [1] , [2]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME0065
Silymarin
Conjugation - Glucuronidation Silymarin [1] , [2]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042
Silymarin
Conjugation - Glucuronidation Silymarin [1] , [2]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME0049
Silymarin
Conjugation - Glucuronidation Silymarin [1] , [2]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040
Silymarin
Conjugation - Glucuronidation Silymarin [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Silymarin DR1913 Phase 4 Fatty liver disease
References
1 Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases
2 Metabolism, Transport and Drug-Drug Interactions of Silymarin

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