Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005298)
Formula Reactant Clorazepic acid Product Nordazepam
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005297 Clorazepic acid Oxazepam Unclear Clorazepic acid [1]
MR005299 Clorazepic acid p-Hydroxynordiazepam Unclear Clorazepic acid [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011243 Chlordiazepoxide Desmethyldiazepam Unclear - Unclear Chlordiazepoxide [3]
MR000819 Diazepam Desmethyldiazepam Unclear Diazepam [4], [5]
MR011025 Halazepam Desmethyl-diazepam Unclear - Unclear Halazepam [6]
MR002107 Prazepam Nordazepam Oxidation - N-Dealkylation Prazepam [7], [8], [9]
MR001328 Diazepam Nordazepam Unclear Ketazolam [10], [5]
MR005847 Diazepam Medazepam metabolite Oxidation - N-demethylation Medazepam [11], [12]
MR005840 Medazepam metabolite Medazepam metabolite Unclear Medazepam [11], [13]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011026 Desmethyl-diazepam Oxazepam Unclear - Unclear Halazepam [6]
MR005841 Medazepam metabolite Oxazepam Unclear Medazepam [11], [13]
References
1 Determination of clorazepate and its major metabolites in blood and urine by electron capture gas-liquid chromatography
2 DrugBank(Pharmacology-Metabolism):Clorazepic acid
3 Postmortem Brain and Blood Reference Concentrations of Alprazolam, Bromazepam, Chlordiazepoxide, Diazepam, and their Metabolites and a Review of the Literature
4 DrugBank(Pharmacology-Metabolism)Diazepam
5 Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs R D. 2022 Mar;22(1):43-50. doi: 10.1007/s40268-021-00375-y.
6 Pharmacokinetics and metabolism of halazepam in naive and dependent dogs
7 Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects. Drug Metab Rev. 2017 Nov;49(4):451-463.
8 Prazepam metabolism by man Clin Pharmacol Ther. 1970 Nov-Dec;11(6):890-7. doi: 10.1002/cpt1970116890.
9 Prazepam metabolites in dog urine J Pharm Sci. 1970 Mar;59(3):322-5. doi: 10.1002/jps.2600590309.
10 Urinary diazepam metabolite distribution in a chronic pain population J Anal Toxicol. 2014 Apr;38(3):135-42. doi: 10.1093/jat/bku001.
11 Metabolism of 14C-medazepam hydrochloride in dog, rat and man
12 Plasma concentrations of medazepam and its metabolites after oral administration
13 Further studies on medazepam metabolism in the rat

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