Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002107)
Formula Reactant Prazepam Product Nordazepam
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002106 Prazepam 3-hydroxyprazepam Oxidation - Hydroxylation Prazepam [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011243 Chlordiazepoxide Desmethyldiazepam Unclear - Unclear Chlordiazepoxide [3]
MR005298 Clorazepic acid Nordazepam Oxidation - N-demethylation Clorazepic acid [4]
MR000819 Diazepam Desmethyldiazepam Unclear Diazepam [5], [6]
MR011025 Halazepam Desmethyl-diazepam Unclear - Unclear Halazepam [7]
MR001328 Diazepam Nordazepam Unclear Ketazolam [8], [6]
MR005847 Diazepam Medazepam metabolite Oxidation - N-demethylation Medazepam [9], [10]
MR005840 Medazepam metabolite Medazepam metabolite Unclear Medazepam [9], [11]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011026 Desmethyl-diazepam Oxazepam Unclear - Unclear Halazepam [7]
MR005841 Medazepam metabolite Oxazepam Unclear Medazepam [9], [11]
References
1 Prazepam metabolism by man Clin Pharmacol Ther. 1970 Nov-Dec;11(6):890-7. doi: 10.1002/cpt1970116890.
2 Prazepam metabolites in dog urine J Pharm Sci. 1970 Mar;59(3):322-5. doi: 10.1002/jps.2600590309.
3 Postmortem Brain and Blood Reference Concentrations of Alprazolam, Bromazepam, Chlordiazepoxide, Diazepam, and their Metabolites and a Review of the Literature
4 Determination of clorazepate and its major metabolites in blood and urine by electron capture gas-liquid chromatography
5 DrugBank(Pharmacology-Metabolism)Diazepam
6 Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs R D. 2022 Mar;22(1):43-50. doi: 10.1007/s40268-021-00375-y.
7 Pharmacokinetics and metabolism of halazepam in naive and dependent dogs
8 Urinary diazepam metabolite distribution in a chronic pain population J Anal Toxicol. 2014 Apr;38(3):135-42. doi: 10.1093/jat/bku001.
9 Metabolism of 14C-medazepam hydrochloride in dog, rat and man
10 Plasma concentrations of medazepam and its metabolites after oral administration
11 Further studies on medazepam metabolism in the rat

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