Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005306)
Formula
CYP1A1 ...
SVG example
Epoxidation
Reactant Coumarin Product Coumarin 3,4-epoxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - Epoxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005310 Coumarin 3-Hydroxycoumarin Oxidation - Aromatic hydroxylation Coumarin [1]
MR005311 Coumarin 4-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005312 Coumarin 5-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005313 Coumarin 6-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005309 Coumarin 7-Hydroxycoumarin Oxidation - Hydroxy Aromaticlation Coumarin [1], [3]
MR005314 Coumarin 8-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005316 Coumarin O-Hydroxyphenyl-propionic Acid Unclear Coumarin [2]
MR005315 Coumarin O-Hydroxyphenylethanol Unclear Coumarin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005307 Coumarin 3,4-epoxide O-Hydroxyphenyl-acetaldehyde Unclear Coumarin [1]
References
1 Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation
2 Coumarin metabolism by rat esophageal microsomes and cytochrome P450 2A3
3 Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation

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