Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005310)
Formula
SVG example
Aromatic hydroxylation
Reactant Coumarin Product 3-Hydroxycoumarin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Aromatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005311 Coumarin 4-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [1]
MR005312 Coumarin 5-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [1]
MR005313 Coumarin 6-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [1]
MR005309 Coumarin 7-Hydroxycoumarin Oxidation - Hydroxy Aromaticlation Coumarin [2], [3]
MR005314 Coumarin 8-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [1]
MR005306 Coumarin Coumarin 3,4-epoxide Oxidation - Epoxidation Coumarin [2]
MR005316 Coumarin O-Hydroxyphenyl-propionic Acid Unclear Coumarin [1]
MR005315 Coumarin O-Hydroxyphenylethanol Unclear Coumarin [2]
References
1 Coumarin metabolism by rat esophageal microsomes and cytochrome P450 2A3
2 Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation
3 Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation

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