Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005309)
Formula
CYP1A1 ...
SVG example
Hydroxy Aromaticlation
Reactant Coumarin Product 7-Hydroxycoumarin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - Hydroxy Aromaticlation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005310 Coumarin 3-Hydroxycoumarin Oxidation - Aromatic hydroxylation Coumarin [1]
MR005311 Coumarin 4-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005312 Coumarin 5-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005313 Coumarin 6-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005314 Coumarin 8-Hydroxycoumarin Oxidation - Hydrolyzationn Coumarin [2]
MR005306 Coumarin Coumarin 3,4-epoxide Oxidation - Epoxidation Coumarin [1]
MR005316 Coumarin O-Hydroxyphenyl-propionic Acid Unclear Coumarin [2]
MR005315 Coumarin O-Hydroxyphenylethanol Unclear Coumarin [1]
References
1 Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation
2 Coumarin metabolism by rat esophageal microsomes and cytochrome P450 2A3

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