Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005317)
Formula
CYP3A4 ...
SVG example
N-demethylation
Reactant Cyamemazine Product N-desmethyl cyamemazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005318 Cyamemazine Cyamemazine sulfoxide Oxidation - Oxidationn Cyamemazine [1], [2]
References
1 Active cyamemazine metabolites in patients treated with cyamemazine (Tercian?): influence on cerebral dopamine D2 and serotonin 5-HT (2A) receptor occupancy as measured by positron emission tomography (PET)
2 Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci. 2007 Dec;32(4-5):357-66.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.