Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005446)
Formula
UGT1A1 ...
SVG example
Oxidationn defluorination; glutathione conjugation
Reactant GSK-1265744 Product Cabotegravir M3
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Multi-steps Reaction - Oxidationn defluorination; glutathione conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005445 GSK-1265744 Cabotegravir M1 Conjugation - Glucuronidation GSK-1265744 [1]
MR005447 GSK-1265744 Cabotegravir M2 Conjugation - Glucose Conjugation GSK-1265744 [1]
MR005448 GSK-1265744 Cabotegravir M4 Multi-steps Reaction - Oxidationn defluorination; glutathione conjugation GSK-1265744 [1]
MR005449 GSK-1265744 Cabotegravir M5 Oxidation - Oxidationn GSK-1265744 [1]
MR007469 GSK-1265744 GSK-1265744 M1 Conjugation - O-glucuronidation GSK-1265744 [1]
MR007470 GSK-1265744 GSK-1265744 M2 Conjugation - O-glucuronidation GSK-1265744 [1]
References
1 Disposition and metabolism of cabotegravir: a comparison of biotransformation and excretion between different species and routes of administration in humans. Xenobiotica. 2016;46(2):147-62.

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