Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007469)
Formula
UGT1A1 ...
SVG example
O-glucuronidation
Reactant GSK-1265744 Product GSK-1265744 M1
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005445 GSK-1265744 Cabotegravir M1 Conjugation - Glucuronidation GSK-1265744 [1]
MR005447 GSK-1265744 Cabotegravir M2 Conjugation - Glucose Conjugation GSK-1265744 [1]
MR005446 GSK-1265744 Cabotegravir M3 Multi-steps Reaction - Oxidationn defluorination; glutathione conjugation GSK-1265744 [1], [2]
MR005448 GSK-1265744 Cabotegravir M4 Multi-steps Reaction - Oxidationn defluorination; glutathione conjugation GSK-1265744 [1]
MR005449 GSK-1265744 Cabotegravir M5 Oxidation - Oxidationn GSK-1265744 [1]
MR007470 GSK-1265744 GSK-1265744 M2 Conjugation - O-glucuronidation GSK-1265744 [1]
References
1 Disposition and metabolism of cabotegravir: a comparison of biotransformation and excretion between different species and routes of administration in humans. Xenobiotica. 2016;46(2):147-62.
2 Correction to "Mechanistic Basis of Cabotegravir-Glucuronide Disposition in Humans"

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