Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005448)
Formula Reactant GSK-1265744 Product Cabotegravir M4
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Oxidationn defluorination; glutathione conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005445 GSK-1265744 Cabotegravir M1 Conjugation - Glucuronidation GSK-1265744 [1]
MR005447 GSK-1265744 Cabotegravir M2 Conjugation - Glucose Conjugation GSK-1265744 [1]
MR005446 GSK-1265744 Cabotegravir M3 Multi-steps Reaction - Oxidationn defluorination; glutathione conjugation GSK-1265744 [1], [2]
MR005449 GSK-1265744 Cabotegravir M5 Oxidation - Oxidationn GSK-1265744 [1]
MR007469 GSK-1265744 GSK-1265744 M1 Conjugation - O-glucuronidation GSK-1265744 [1]
MR007470 GSK-1265744 GSK-1265744 M2 Conjugation - O-glucuronidation GSK-1265744 [1]
References
1 Disposition and metabolism of cabotegravir: a comparison of biotransformation and excretion between different species and routes of administration in humans. Xenobiotica. 2016;46(2):147-62.
2 Correction to "Mechanistic Basis of Cabotegravir-Glucuronide Disposition in Humans"

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.