Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005524)
Formula
CYP3A4 ...
SVG example
Oxidationn
Reactant Lonafarnib Product Lonafarnib metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005525 Lonafarnib metabolite M1 Lonafarnib metabolite M2 Other reaction - Dehydration Lonafarnib [1], [2]
References
1 Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar). Drug Metab Dispos. 2006 Apr;34(4):628-35.
2 Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration

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