Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005680)
Formula
SVG example
N-dealkylation
Reactant Zolmitriptan Product N-Desmethylzolmitriptan
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005681 N-Desmethylzolmitriptan Indole ethyl alcohol zolmitriptan derivative Oxidation - Deamination Zolmitriptan [1], [2]
References
1 Indolealkylamines: biotransformations and potential drug-drug interactions
2 Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. Xenobiotica. 1999 Aug;29(8):847-57.

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