Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005735)
Formula
SVG example
Reactant 13-cis-retinoic acid Product 9-cis-retinoic acid
Reactant Info Product Info
Metabolic Enzyme Sphingolipid delta(4)-desaturase DES1 (DES1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002986 Alitretinoin 13-cis-retinoic acid Unclear - Unclear Alitretinoin [1]
MR009631 Tretinoin 13-cis RA Other reaction - Isomerization Tretinoin [2], [3]
MR005734 Retinoic acid 13-cis-retinoic acid Unclear Beta carotene [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009633 13-cis RA 13-cis-4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [2]
MR009632 13-cis RA 13-cis-Retinoyl-beta-glucuronide Conjugation - Glucuronidation Tretinoin [5], [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009634 Tretinoin 9-cis RA Other reaction - Isomerization Tretinoin [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009635 9-cis RA 9-cis-4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [2]
References
1 The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis Br J Dermatol. 2014 Feb;170(2):408-14. doi: 10.1111/bjd.12546.
2 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
3 Retinoic acid metabolism and mechanism of action: a review
4 #NAME?
5 Clinical pharmacokinetics of tretinoin
6 13-cis retinoyl-beta-glucuronide in lacrimal gland fluid of rabbits treated with 13-cis retinoic acid

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