Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009631)
Formula
CYP2C8 ...
SVG example
Isomerization
Reactant Tretinoin Product 13-cis RA
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Other reaction - Isomerization
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009636 Tretinoin 18-OH-RA Oxidation - Hydroxylation Tretinoin [1], [2], [3]
MR009637 Tretinoin 3,4-Didehydroretinoic acid Oxidation - Oxidation Tretinoin [4]
MR009626 Tretinoin 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation Tretinoin [1], [3]
MR009629 Tretinoin 5,6-epoxy-RA Oxidation - Ring epoxidation Tretinoin [2], [2], [1]
MR009634 Tretinoin 9-cis RA Other reaction - Isomerization Tretinoin [3], [2]
MR009638 Tretinoin Retinotaurine Oxidation - Oxidation Tretinoin [4]
MR009639 Tretinoin Retinoyl beta-glucuronide Conjugation - Glucuronidation Tretinoin [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002986 Alitretinoin 13-cis-retinoic acid Unclear - Unclear Alitretinoin [5]
MR005734 Retinoic acid 13-cis-retinoic acid Unclear Beta carotene [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009633 13-cis RA 13-cis-4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [3]
MR009632 13-cis RA 13-cis-Retinoyl-beta-glucuronide Conjugation - Glucuronidation Tretinoin [4], [7]
MR005735 13-cis-retinoic acid 9-cis-retinoic acid Unclear Beta carotene [6]
References
1 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
2 Retinoic acid metabolism and mechanism of action: a review
3 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
4 Clinical pharmacokinetics of tretinoin
5 The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis Br J Dermatol. 2014 Feb;170(2):408-14. doi: 10.1111/bjd.12546.
6 #NAME?
7 13-cis retinoyl-beta-glucuronide in lacrimal gland fluid of rabbits treated with 13-cis retinoic acid

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