Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009632)
Formula
SVG example
Glucuronidation
Reactant 13-cis RA Product 13-cis-Retinoyl-beta-glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002986 Alitretinoin 13-cis-retinoic acid Unclear - Unclear Alitretinoin [1]
MR009631 Tretinoin 13-cis RA Other reaction - Isomerization Tretinoin [2], [3]
MR005734 Retinoic acid 13-cis-retinoic acid Unclear Beta carotene [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009633 13-cis RA 13-cis-4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [2]
MR005735 13-cis-retinoic acid 9-cis-retinoic acid Unclear Beta carotene [4]
References
1 The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis Br J Dermatol. 2014 Feb;170(2):408-14. doi: 10.1111/bjd.12546.
2 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
3 Retinoic acid metabolism and mechanism of action: a review
4 #NAME?

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