Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005734)
Formula
SVG example
Reactant Retinoic acid Product 13-cis-retinoic acid
Reactant Info Product Info
Metabolic Enzyme Sphingolipid delta(4)-desaturase DES1 (DES1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002987 Alitretinoin all-trans-retinoic acid Unclear - Unclear Alitretinoin [1]
MR001261 Isotretinoin All-trans-retinoic acid Unclear Isotretinoin [2], [3], [4], [5]
MR005731 Retinal Retinoic acid Unclear Beta carotene [6]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001252 All-trans-retinoic acid 16-hydroxyisotretinoin Oxidation - 16-Hydroxylation Isotretinoin [2]
MR001253 All-trans-retinoic acid 18-hydroxyisotretinoin Oxidation - 18-Hydroxylation Isotretinoin [2]
MR001254 All-trans-retinoic acid 4-hydroxyretinoic acid Oxidation - 4-Hydroxylation Isotretinoin [7]
MR005732 Retinoic acid 4-Oxoretinoic acid Unclear Beta carotene [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002986 Alitretinoin 13-cis-retinoic acid Unclear - Unclear Alitretinoin [1]
MR009631 Tretinoin 13-cis RA Other reaction - Isomerization Tretinoin [8], [9]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009633 13-cis RA 13-cis-4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [8]
MR009632 13-cis RA 13-cis-Retinoyl-beta-glucuronide Conjugation - Glucuronidation Tretinoin [10], [11]
MR005735 13-cis-retinoic acid 9-cis-retinoic acid Unclear Beta carotene [6]
References
1 The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis Br J Dermatol. 2014 Feb;170(2):408-14. doi: 10.1111/bjd.12546.
2 Human biliary metabolites of isotretinoin: identification, quantification, synthesis, and biological activity Xenobiotica. 1990 Feb;20(2):193-207. doi: 10.3109/00498259009047155.
3 Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic Drug Metab Dispos. 2022 Jul;50(7):1042-1052. doi: 10.1124/dmd.122.000882.
4 The use of isotretinoin in acne Dermatoendocrinol. 2009 May;1(3):162-9. doi: 10.4161/derm.1.3.9364.
5 The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone. Clin Pharmacol Ther. 2004 May;75(5):464-75.
6 #NAME?
7 DrugBank(Pharmacology-Metabolism)Isotretinoin
8 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
9 Retinoic acid metabolism and mechanism of action: a review
10 Clinical pharmacokinetics of tretinoin
11 13-cis retinoyl-beta-glucuronide in lacrimal gland fluid of rabbits treated with 13-cis retinoic acid

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