Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005816)
Formula
SVG example
O-demethylation
Reactant Methoxybufotenin Product Bufotenine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005818 Methoxybufotenin 5-methoxyindoleacetic acid Unclear Methoxybufotenin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003311 5-Methoxytryptamine Bufotenine Conjugation - Methylation Melatonin [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005817 Bufotenine 5-hydroxyindoleacetic acid Unclear Methoxybufotenin [1]
MR003313 Bufotenine N,N-Dimethyltryptamine Unclear Melatonin [2]
References
1 Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Curr Drug Metab. 2010 Oct;11(8):659-66.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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