Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005862)
Formula
SVG example
Hydrolyzationn
Reactant L-tyrosine Product DOPA
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005861 L-tyrosine Carbon dioxide Unclear L-tyrosine [1]
MR005864 L-tyrosine p-hydroxyphenylacetate Unclear L-tyrosine [1]
MR005863 L-tyrosine p-hydroxyphenylpyruvate Unclear L-tyrosine [1]
MR005860 L-tyrosine Tyramine Unclear L-tyrosine [2], [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009123 ABBV-951 Levodopa Unclear - Unclear ABBV-951 [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003504 DOPA 3,4-dihydroxyphenylpropionic acid(DPPA) Unclear L-phenylalanine [4]
MR003508 DOPA DOPP Unclear L-phenylalanine [4]
References
1 Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver
2 Tyrosine decarboxylase from Lactobacillus brevis: soluble expression and characterization. Protein Expr Purif. 2014 Feb;94:33-9.
3 Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson's Disease
4 Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine Res Microbiol. 2007 Jul-Aug;158(6):506-11. doi: 10.1016/j.resmic.2007.04.008.

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