Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005976)
Formula
SVG example
Aromatic hydroxylation
Reactant GV-150526 Product p-OH-gavestinel
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Aromatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005979 GV-150526 Gavestinel acyl glucuronid Conjugation - Glucuronidation GV-150526 [1]
MR005978 GV-150526 p-Hydroxygavestinel Oxidation - Hydrolyzationn GV-150526 [2]
MR005977 GV-150526 TGavestinel sulfate (M1) Unclear GV-150526 [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 DrugBank(Pharmacology-Metabolism): GV-150526 Tretazicar

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