Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005979)
Formula
UGT1A9 ...
SVG example
Glucuronidation
Reactant GV-150526 Product Gavestinel acyl glucuronid
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005978 GV-150526 p-Hydroxygavestinel Oxidation - Hydrolyzationn GV-150526 [1]
MR005976 GV-150526 p-OH-gavestinel Oxidation - Aromatic hydroxylation GV-150526 [2]
MR005977 GV-150526 TGavestinel sulfate (M1) Unclear GV-150526 [2]
References
1 DrugBank(Pharmacology-Metabolism): GV-150526 Tretazicar
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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