Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006048)
Formula
CYP3A4 ...
SVG example
Monohydroxylation
Reactant EMD-128130 Product Sarizotan metabolite M364D
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Monohydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006041 EMD-128130 EMD 329989 Oxidation - Hydrolyzationn EMD-128130 [1]
MR006050 EMD-128130 Sarizotan metabolite M203 Conjugation - Glycosylation EMD-128130 [2]
MR006045 EMD-128130 Sarizotan metabolite M364A Oxidation - Hydrolyzationn EMD-128130 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006049 Sarizotan metabolite M364D Sarizotan metabolite M203 Unclear EMD-128130 [1]
References
1 In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug-metabolizing enzyme identification, and evaluation of cytochrome p450 inhibition. Drug Metab Dispos. 2010 Jun;38(6):905-16.
2 Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats

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