Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006050)
Formula
CYP1A2 ...
SVG example
Glycosylation
Reactant EMD-128130 Product Sarizotan metabolite M203
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Conjugation - Glycosylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006041 EMD-128130 EMD 329989 Oxidation - Hydrolyzationn EMD-128130 [1]
MR006045 EMD-128130 Sarizotan metabolite M364A Oxidation - Hydrolyzationn EMD-128130 [1]
MR006048 EMD-128130 Sarizotan metabolite M364D Oxidation - Monohydroxylation EMD-128130 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006043 EMD 329989 Sarizotan metabolite M203 Unclear EMD-128130 [1]
MR006046 Sarizotan metabolite M364A Sarizotan metabolite M203 Unclear EMD-128130 [1]
MR006049 Sarizotan metabolite M364D Sarizotan metabolite M203 Unclear EMD-128130 [1]
MR006044 Sarizotan metabolite M362 Sarizotan metabolite M203 Unclear EMD-128130 [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006047 Sarizotan metabolite M203 Sarizotan metabolite M217 Oxidation - Oxidationn EMD-128130 [1]
References
1 In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug-metabolizing enzyme identification, and evaluation of cytochrome p450 inhibition. Drug Metab Dispos. 2010 Jun;38(6):905-16.

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