Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006053)
Formula
SVG example
Conjugation
Reactant Hydroquinone Product Quinol glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - Conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001158 Hydroquinone 2,3,5-tris(glutathion-S-yl)Hydroquinone Unclear Hydroquinone [1]
MR001157 Hydroquinone p-Benzoquinone Oxidation - Oxidation Hydroquinone [2]
MR007415 Hydroquinone Ascorbate Unclear CoQ-10 [3]
MR007416 Hydroquinone Q acid I and Q acid II Unclear CoQ-10 [3]
MR006052 Hydroquinone Quinol sulfate Conjugation - Conjugation ENT-1814 [4]
MR007414 Hydroquinone Tocopherol Unclear CoQ-10 [3]
MR008147 Hydroquinone Menatetrenone Unclear - Unclear Phytonadione [5]
References
1 Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone Chem Res Toxicol. 2001 Jan;14(1):25-33. doi: 10.1021/tx000161g.
2 Hydroquinone, a bioreactive metabolite of benzene, inhibits apoptosis in myeloblasts Stem Cells. 1996 Nov;14(6):730-42. doi: 10.1002/stem.140730.
3 Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics
4 Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite. Toxicol Lett. 2001 Dec 15;125(1-3):117-23.
5 Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis

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