Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008147)
Formula
NQO1 ...
SVG example
Unclear
Reactant Hydroquinone Product Menatetrenone
Reactant Info Product Info
Metabolic Enzyme Quinone reductase 1 (NQO1) DME Info
VKORC1-like protein 1 (VKORC1L1) DME Info
Vitamin K1 2,3-epoxide reductase 1 (VKOR) DME Info
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001158 Hydroquinone 2,3,5-tris(glutathion-S-yl)Hydroquinone Unclear Hydroquinone [1]
MR001157 Hydroquinone p-Benzoquinone Oxidation - Oxidation Hydroquinone [2]
MR007415 Hydroquinone Ascorbate Unclear CoQ-10 [3]
MR007416 Hydroquinone Q acid I and Q acid II Unclear CoQ-10 [3]
MR006053 Hydroquinone Quinol glucuronide Conjugation - Conjugation ENT-1814 [4]
MR006052 Hydroquinone Quinol sulfate Conjugation - Conjugation ENT-1814 [4]
MR007414 Hydroquinone Tocopherol Unclear CoQ-10 [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008148 Menatetrenone Vitamin K epoxide Unclear - Unclear Phytonadione [5]
References
1 Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone Chem Res Toxicol. 2001 Jan;14(1):25-33. doi: 10.1021/tx000161g.
2 Hydroquinone, a bioreactive metabolite of benzene, inhibits apoptosis in myeloblasts Stem Cells. 1996 Nov;14(6):730-42. doi: 10.1002/stem.140730.
3 Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics
4 Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite. Toxicol Lett. 2001 Dec 15;125(1-3):117-23.
5 VKORC1L1, an enzyme mediating the effect of vitamin K in liver and extrahepatic tissues. Nutrients. 2018 Jul 26;10(8). pii: E970.

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