Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006072)
Formula Reactant Z-4828 Product Ifosfamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006073 Z-4828 L-cyclophosphamide Oxidation - N-dealkylation Z-4828 [1]
MR006071 Z-4828 L-ifosfamide Oxidation - Aliphatic hydroxylation Z-4828 [1]
References
1 Metabolism and transport of oxazaphosphorines and the clinical implications Drug Metab Rev. 2005;37(4):611-703. doi: 10.1080/03602530500364023.

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