Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006146)
Formula
SVG example
Aliphatic hydroxylation
Reactant NOVA-63035 Product 6beta-Hydroxydexamethasone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006143 NOVA-63035 11-dehydrodexamethasone Reduction - Reduction NOVA-63035 [1]
MR006145 NOVA-63035 6alpha-Hydroxydexamethasone Oxidation - Aliphatic hydroxylation NOVA-63035 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000792 Dexamethasone sodium phosphate 6beta-hydroxydexamethasone Oxidation - Hydroxylation Dexamethasone sodium phosphate [3]
References
1 Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction J Clin Endocrinol Metab. 1997 May;82(5):1598-602. doi: 10.1210/jcem.82.5.3936.
2 Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation
3 Dexamethasone metabolism in vitro: species differences J Steroid Biochem Mol Biol. 1997 Jul;62(4):345-52. doi: 10.1016/s0960-0760(97)00038-1.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.