General Information of This Metabolic Reaction (MR) (ID:
MR006145) |
Formula |
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Reactant |
NOVA-63035 |
Product |
6alpha-Hydroxydexamethasone |
Reactant Info
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Product Info
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Metabolic Enzyme
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Cytochrome P450 3A4 (CYP3A4)
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DME Info
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Metabolic Type
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Oxidation
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Aliphatic hydroxylation
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Other MR(s) Related to The Reactant of This MR |
Other MR(s) That Metabolize The Reactant of This MR
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Other MR(s) Related to The Product of This MR |
Other MR(s) That Produce The Product of This MR
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References |
1 |
Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction J Clin Endocrinol Metab. 1997 May;82(5):1598-602. doi: 10.1210/jcem.82.5.3936.
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2 |
Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation
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3 |
Dexamethasone metabolism in vitro: species differences J Steroid Biochem Mol Biol. 1997 Jul;62(4):345-52. doi: 10.1016/s0960-0760(97)00038-1.
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