Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006150)
Formula
CYP3A4 ...
SVG example
Oxidationn
Reactant TRV-130 Product Oxy-oliceridine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006152 TRV-130 TRV0109662 Oxidation - N-dealkylation TRV-130 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006151 Oxy-oliceridine TRV0306954 Conjugation - Glucuronidation TRV-130 [1]
References
1 The Utilization of Mu-Opioid Receptor Biased Agonists: Oliceridine, an Opioid Analgesic with Reduced Adverse Effects

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.