Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006164)
Formula
SVG example
Hydrolyzationn
Reactant Terfenadine Product Terfenadine alcohol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006166 Terfenadine Azacyclonol Oxidation - N-dealkylation Terfenadine [1]
MR006168 Terfenadine Terfenadine glucuronide Conjugation - Glucuronidation Terfenadine [2]
MR006167 Terfenadine Terfenadine phosphate Conjugation - Phosphorylation Terfenadine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006165 Terfenadine alcohol Fexofenadine Oxidation - Oxidationn Terfenadine [1]
References
1 Analysis of hydroxylated and N-dealkylated metabolites of terfenadine in microsomal incubates by liquid chromatography--mass spectrometry
2 Distribution of terfenadine and its metabolites in locusts studied by desorption electrospray ionization mass spectrometry imaging

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