Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006166)
Formula
SVG example
N-dealkylation
Reactant Terfenadine Product Azacyclonol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006164 Terfenadine Terfenadine alcohol Oxidation - Hydrolyzationn Terfenadine [1]
MR006168 Terfenadine Terfenadine glucuronide Conjugation - Glucuronidation Terfenadine [2]
MR006167 Terfenadine Terfenadine phosphate Conjugation - Phosphorylation Terfenadine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007796 Fexofenadine MDL 4829 (Azacyclonol) Unclear - Unclear Fexofenadine [3]
References
1 Analysis of hydroxylated and N-dealkylated metabolites of terfenadine in microsomal incubates by liquid chromatography--mass spectrometry
2 Distribution of terfenadine and its metabolites in locusts studied by desorption electrospray ionization mass spectrometry imaging
3 The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates

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