General Information of This Metabolic Reaction (MR) (ID:
MR006191) |
Formula |
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Reactant |
Tienilic acid |
Product |
Tienilic acid-s-oxide |
Reactant Info
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Product Info
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Metabolic Enzyme
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Cytochrome P450 2C8 (CYP2C8)
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DME Info
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Cytochrome P450 2C9 (CYP2C9)
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DME Info
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Metabolic Type
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Oxidation
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S-oxidation
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Other MR(s) Related to The Reactant of This MR |
Other MR(s) That Metabolize The Reactant of This MR
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References |
1 |
Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation
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2 |
Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10
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3 |
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
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