Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000398)
DM Name	Thiophene-4,5-epoxide

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2C18 (CYP2C18)	DME0017	Tienilic acid	Oxidation - Epoxidation	Tienilic acid	[1]
Cytochrome P450 2C8 (CYP2C8)	DME0018	Tienilic acid	Oxidation - Epoxidation	Tienilic acid	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Tienilic acid	Oxidation - Epoxidation	Tienilic acid	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Suprofen	Unclear - Unclear	Suprofen	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Tienilic acid	Oxidation - Epoxidation	Tienilic acid	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 2C9 (CYP2C9)	DME0019	Suprofen metabolite M2	Unclear - Unclear	Suprofen	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Suprofen		DR1520	Approved		Iris sphincter disorder

Tienilic acid		DR1593	Phase 4		Congestive heart failure

References
1	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.