Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006223)
Formula
SVG example
Oxidationn
Reactant Tropisetron Product Tropisetron N-Oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006220 Tropisetron 5-hydroxy tropisetron Oxidation - Hydrolyzationn Tropisetron [1], [2], [3]
MR006221 Tropisetron 6-hydroxy tropisetron Oxidation - Hydrolyzationn Tropisetron [1], [2], [3]
MR006222 Tropisetron 7-hydroxy tropisetron Oxidation - Hydrolyzationn Tropisetron [1], [2], [3]
MR006224 Tropisetron N-demethyl Tropisetron Oxidation - N-demethylation Tropisetron [3]
References
1 Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of dolasetron. Comparison with other indole-containing 5-HT3 antagonists. Drug Metab Dispos. 1996 May;24(5):602-9.
2 The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron. Drug Metab Dispos. 1994 Mar-Apr;22(2):269-74.
3 Pharmacokinetics and metabolism of the 5-hydroxytryptamine antagonist tropisetron after single oral doses in humans

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