Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006364)
Formula Reactant HVA Product Sulfate conjugate of HVA
Reactant Info Product Info
Metabolic Enzyme phenolsulfotransferase (PST) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006363 DOPAC HVA Unclear SC-47945 [1]
MR006628 DOPAC HVA Unclear Dopamine hydrochloride [2]
MR006631 MHPA HVA Unclear Dopamine hydrochloride [2]
MR001496 3,4-dihydroxyphenylacetic acid Homovanillic acid Conjugation - O-Methylation Levodopa [3]
MR001493 3-methoxy-4-hydroxyacetaldehyde Homovanillic acid Oxidation - Oxidation Levodopa [3]
MR008914 3-methoxytyramine Homovanillic acid Unclear - Unclear Docarpamine [4]
⏷ Show the Full List of MR
References
1 Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50.
2 Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain
3 DrugBank(Pharmacology-Metabolism)Levodopa
4 Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs

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