Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008914)
Formula
SVG example
Unclear
Reactant 3-methoxytyramine Product Homovanillic acid
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006629 Dopamine hydrochloride 3-MT Unclear Dopamine hydrochloride [1]
MR001485 Dopamine 3-Methoxytyramine Conjugation - O-Methylation Levodopa [2]
MR008913 Dopamine 3-methoxytyramine Unclear - Unclear Docarpamine [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006630 3-MT MHPA Unclear Dopamine hydrochloride [1]
MR001492 3-Methoxytyramine 3-methoxy-4-hydroxyacetaldehyde Oxidation - Oxidative Deamination Levodopa [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006363 DOPAC HVA Unclear SC-47945 [4]
MR006628 DOPAC HVA Unclear Dopamine hydrochloride [1]
MR006631 MHPA HVA Unclear Dopamine hydrochloride [1]
MR001496 3,4-dihydroxyphenylacetic acid Homovanillic acid Conjugation - O-Methylation Levodopa [2]
MR001493 3-methoxy-4-hydroxyacetaldehyde Homovanillic acid Oxidation - Oxidation Levodopa [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006364 HVA Sulfate conjugate of HVA Unclear SC-47945 [4]
References
1 Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain
2 DrugBank(Pharmacology-Metabolism)Levodopa
3 Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs
4 Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50.

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