Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001493)
Formula Reactant 3-methoxy-4-hydroxyacetaldehyde Product Homovanillic acid
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001492 3-Methoxytyramine 3-methoxy-4-hydroxyacetaldehyde Oxidation - Oxidative Deamination Levodopa [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006363 DOPAC HVA Unclear SC-47945 [2]
MR006628 DOPAC HVA Unclear Dopamine hydrochloride [3]
MR006631 MHPA HVA Unclear Dopamine hydrochloride [3]
MR001496 3,4-dihydroxyphenylacetic acid Homovanillic acid Conjugation - O-Methylation Levodopa [1]
MR008914 3-methoxytyramine Homovanillic acid Unclear - Unclear Docarpamine [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006364 HVA Sulfate conjugate of HVA Unclear SC-47945 [2]
References
1 DrugBank(Pharmacology-Metabolism)Levodopa
2 Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50.
3 Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain
4 Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs

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