Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001496)
Formula
SVG example
O-Methylation
Reactant 3,4-dihydroxyphenylacetic acid Product Homovanillic acid
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - O-Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006362 SC-47945 DOPAC Unclear SC-47945 [1]
MR006627 DHPA DOPAC Unclear Dopamine hydrochloride [2]
MR001494 3,4-Dihydroxyphenylacetaldehyde (DOPAL) 3,4-dihydroxyphenylacetic acid Oxidation - Hydroxylation Levodopa [3]
MR008915 Dopamine 3,4-dihydroxyphenylacetic acid Unclear - Unclear Docarpamine [4]
MR004488 3-(3',4'-Dihydroxyphenyl)propionic acid 3'-4'-Dihydroxyphenylacetic acid Unclear VS-12343 [5]
MR003506 DOPL 3,4-dihydroxyphenylacetic acid Unclear L-phenylalanine [6]
MR004403 2-(4-Hydroxyphenyl)acetic acid (3,4-Dihydroxyphenyl)acetic acid Oxidation - Hydrolyzationn N-nonylphenol [7]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006365 DOPAC Sulfate conjugate of DOPAC Unclear SC-47945 [1]
MR008916 3,4-dihydroxyphenylacetic acid 3-hydroxyphenylacetic acid Unclear - Unclear Docarpamine [4]
MR004489 3'-4'-Dihydroxyphenylacetic acid 3'-Hydroxyphenylacetic acid Unclear VS-12343 [5]
MR003507 3,4-dihydroxyphenylacetic acid 3,4-Dihydroxybenzoic acid Unclear L-phenylalanine [6]
MR004494 3'-4'-Dihydroxyphenylacetic acid 3,4-Dihydroxybenzoic acid Unclear VS-12343 [5]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006631 MHPA HVA Unclear Dopamine hydrochloride [2]
MR001493 3-methoxy-4-hydroxyacetaldehyde Homovanillic acid Oxidation - Oxidation Levodopa [3]
MR008914 3-methoxytyramine Homovanillic acid Unclear - Unclear Docarpamine [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006364 HVA Sulfate conjugate of HVA Unclear SC-47945 [1]
References
1 Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50.
2 Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain
3 DrugBank(Pharmacology-Metabolism)Levodopa
4 Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs
5 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
6 Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine Res Microbiol. 2007 Jul-Aug;158(6):506-11. doi: 10.1016/j.resmic.2007.04.008.
7 4-n-nonylphenol degradation by the genus Metarhizium with cytochrome P450 involvement

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