Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006425)
Formula
CYP3A4 ...
SVG example
Demethylation
Reactant R-1124 Product N\demethylated netupitant
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006426 R-1124 Monohydroxy netupitant Oxidation - Hydrolyzationn R-1124 [1]
MR006424 R-1124 Netupitant N-Oxide Oxidation - Oxidationn R-1124 [1]
References
1 Netupitant PET imaging and ADME studies in humans

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