Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006444)
Formula Reactant SB-939 Product SB-939 Metabolite M7
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006440 SB-939 SB-939 Metabolite M1 Oxidation - N-deethylation SB-939 [1]
MR006442 SB-939 SB-939 Metabolite M2/M3/M4 Oxidation - Oxidationn SB-939 [1]
MR006445 SB-939 SB-939 Metabolite M6 Oxidation - Bis-N-deethylation SB-939 [1]
MR006446 SB-939 SB-939 Metabolite M8 Unclear SB-939 [1]
References
1 Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metab Dispos. 2011 Dec;39(12):2219-32.

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