Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006445)
Formula
SVG example
Bis-N-deethylation
Reactant SB-939 Product SB-939 Metabolite M6
Reactant Info Product Info
Metabolic Type Oxidation - Bis-N-deethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006440 SB-939 SB-939 Metabolite M1 Oxidation - N-deethylation SB-939 [1]
MR006442 SB-939 SB-939 Metabolite M2/M3/M4 Oxidation - Oxidationn SB-939 [1]
MR006444 SB-939 SB-939 Metabolite M7 Oxidation - Oxidationn SB-939 [1]
MR006446 SB-939 SB-939 Metabolite M8 Unclear SB-939 [1]
References
1 Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metab Dispos. 2011 Dec;39(12):2219-32.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.