Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006446)
Formula
SVG example
Reactant SB-939 Product SB-939 Metabolite M8
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006440 SB-939 SB-939 Metabolite M1 Oxidation - N-deethylation SB-939 [1]
MR006442 SB-939 SB-939 Metabolite M2/M3/M4 Oxidation - Oxidationn SB-939 [1]
MR006445 SB-939 SB-939 Metabolite M6 Oxidation - Bis-N-deethylation SB-939 [1]
MR006444 SB-939 SB-939 Metabolite M7 Oxidation - Oxidationn SB-939 [1]
References
1 Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metab Dispos. 2011 Dec;39(12):2219-32.

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