Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006440)
Formula
CYP1A2 ...
SVG example
N-deethylation
Reactant SB-939 Product SB-939 Metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-deethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006442 SB-939 SB-939 Metabolite M2/M3/M4 Oxidation - Oxidationn SB-939 [1]
MR006445 SB-939 SB-939 Metabolite M6 Oxidation - Bis-N-deethylation SB-939 [1]
MR006444 SB-939 SB-939 Metabolite M7 Oxidation - Oxidationn SB-939 [1]
MR006446 SB-939 SB-939 Metabolite M8 Unclear SB-939 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006441 SB-939 Metabolite M1 SB-939 Metabolite M5 Oxidation - Oxidationn SB-939 [1]
References
1 Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metab Dispos. 2011 Dec;39(12):2219-32.

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