Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006568)
Formula
SVG example
Demethylation
Reactant Desmethylclomipramine Product 2-hydroxydesmethyl clomipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009009 Clomipramine Desmethylclomipramine Oxidation - N-demethylation Clomipramine [1]
MR006567 Clomipramine hydrochloride Desmethylclomipramine Oxidation - N-demethylation Clomipramine hydrochloride [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006570 Desmethylclomipramine Didesmethylclomipramine Oxidation - N-demethylation Clomipramine hydrochloride [2], [3]
MR009010 Desmethylclomipramine Didesmethylclomipramine Oxidation - N-demethylation Clomipramine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006572 2-hydroxyclomipramine 2-hydroxydesmethyl clomipramine Oxidation - Demethylation Clomipramine hydrochloride [4]
MR009002 2-hydroxyclomipramine 2-hydroxydesmethyl clomipramine Oxidation - Demethylation Clomipramine [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006569 2-hydroxydesmethyl clomipramine 2-hydroxydesmethyl clomipramine glucuronide Conjugation - Glucuronidation Clomipramine hydrochloride [4]
MR009003 2-hydroxydesmethyl clomipramine 2-hydroxydesmethyl clomipramine glucuronide Conjugation - Glucuronidation Clomipramine [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation
3 Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation
4 Determination of clomipramine or imipramine and their mono-demethylated metabolites in human blood or plasma by high-performance liquid chromatography

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