Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009009)
Formula
CYP3A4 ...
SVG example
N-demethylation
Reactant Clomipramine Product Desmethylclomipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009013 Clomipramine 10-OH-clomipramine Oxidation - Aliphatic hydroxylation Clomipramine [1]
MR009001 Clomipramine 2-hydroxyclomipramine Oxidation - 2-hydroxylation Clomipramine [1]
MR009005 Clomipramine 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine [1]
MR009012 Clomipramine 8-OH-clomipramine Oxidation - Aromatic hydroxylation Clomipramine [1]
MR009011 Clomipramine Clomipramine N-oxide Unclear - Unclear Clomipramine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006567 Clomipramine hydrochloride Desmethylclomipramine Oxidation - N-demethylation Clomipramine hydrochloride [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006568 Desmethylclomipramine 2-hydroxydesmethyl clomipramine Oxidation - Demethylation Clomipramine hydrochloride [5]
MR006570 Desmethylclomipramine Didesmethylclomipramine Oxidation - N-demethylation Clomipramine hydrochloride [3], [4]
MR009010 Desmethylclomipramine Didesmethylclomipramine Oxidation - N-demethylation Clomipramine [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 DrugBank(Pharmacology-Metabolism):Clomipramine
3 Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation
4 Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation
5 Determination of clomipramine or imipramine and their mono-demethylated metabolites in human blood or plasma by high-performance liquid chromatography

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