Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006572)
Formula
SVG example
Demethylation
Reactant 2-hydroxyclomipramine Product 2-hydroxydesmethyl clomipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009001 Clomipramine 2-hydroxyclomipramine Oxidation - 2-hydroxylation Clomipramine [1]
MR006571 Clomipramine hydrochloride 2-hydroxyclomipramine Oxidation - 2-hydroxylation Clomipramine hydrochloride [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006573 2-hydroxyclomipramine 2-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine hydrochloride [2]
MR009004 2-hydroxyclomipramine 2-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006568 Desmethylclomipramine 2-hydroxydesmethyl clomipramine Oxidation - Demethylation Clomipramine hydrochloride [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006569 2-hydroxydesmethyl clomipramine 2-hydroxydesmethyl clomipramine glucuronide Conjugation - Glucuronidation Clomipramine hydrochloride [2]
MR009003 2-hydroxydesmethyl clomipramine 2-hydroxydesmethyl clomipramine glucuronide Conjugation - Glucuronidation Clomipramine [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Determination of clomipramine or imipramine and their mono-demethylated metabolites in human blood or plasma by high-performance liquid chromatography

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